Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry

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• 作者：Paula Dá ; vila-Seijo¹ ; ¹⁵ ; ^{pauladavilaseijo@gmail.com} ; Esteban Dauden² ; M.A. Descalzo¹ ; Gregorio Carretero³ ; Jos&eacute ; -Manuel Carrascosa⁴ ; Francisco Vanaclocha⁵ ; Francisco-Jos&eacute ; Gó ; mez-Garcí ; a⁶ ; Pablo De la Cueva-Dobao⁷ ; Enrique Herrera-Ceballos⁸ ; Isabel Belinchó ; n⁹ ; Jos&eacute ; -Luis Ló ; pez-Estebaranz¹⁰ ; Merce Alsina¹¹ ; Jos&eacute ; -Luis Sá ; nchez-Carazo¹² ; Marta Ferrá ; n¹³ ; Rosa Torrado³ ; Carlos Ferrandiz⁴ ; Raquel Rivera⁵ ; Mar Llamas² ; Rafael Jim&eacute ; nez-Puya⁶ ; Ignacio Garcí ; a-Doval¹ ; ¹⁴ ; ; the BIOBADADERM Study GroupBeatriz P&eacute ; rez Zafrilla ; Carlos Muñ ; oz-Santos ; Victoria Mendiola-Ferná ; ndez ; Cristina Sá ; nchez Roldá ; n ; Diana Ruiz-Genao ; Begoñ ; a Echeverrí ; a ; Sagrario Galiano Mejí ; as
• 关键词：BIOBADADERM ; Spanish Registry of Adverse Events for Biological Therapy in Dermatological Diseases ; CI ; confidence interval ; PASI ; Psoriasis Area Severity Index ; RR ; risk ratio ; TNF ; tumor necrosis factor
• 刊名：Journal of Investigative Dermatology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：137
• 期：2
• 页码：313-321
• 全文大小：207 K
• 卷排序：137

文摘

Information regarding the safety of biological drugs prescribed to psoriasis patients on daily and long-term bases is insufficient. We used data from the BIOBADADERM registry (Spanish Registry of Adverse Events for Biological Therapy in Dermatological Diseases) to generate crude rates of infection during therapy with systemic drugs, including biological drugs (infliximab, etanercept, adalimumab, and ustekinumab) and nonbiological drugs (acitretin, cyclosporine, and methotrexate). We also calculated unadjusted and adjusted risk ratios (RRs) (with propensity score adjustment) of infection, serious infections, and recurrent infections of systemic therapies compared with methotrexate, using Poisson regression. Our study included records of 2,153 patients (7,867.5 person-years). The adjusted RR of overall infection was significantly increased in the groups treated with adalimumab with methotrexate (adjusted RR = 2.13, 95% confidence interval [CI] = 1.2–3.7), infliximab (adjusted RR = 1.71, 95% CI = 1.1–2.65), cyclosporine (adjusted RR = 1.58, 95% CI = 1.17–2.15), ustekinumab with methotrexate (adjusted RR = 1.56, 95% CI = 1.08–2.25), and etanercept (adjusted RR = 1.34, 95% CI: 1.02–1.76) compared with methotrexate alone. Cyclosporine had a significant risk of serious infection (adjusted RR = 3.12, 95% CI = 1.1–8.8), followed by adalimumab combined with methotrexate (adjusted RR = 3.28, 95% CI = 0.8–13.5). Adalimumab in combination with methotrexate had the highest risk of infection recurrence (adjusted RR = 4.33, 95% CI = 2.27–8.24).