Parental provisioning and offspring fitness: size matters
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- 作者：P.L. Schwagmeyer ; Douglas W. Mock
- 关键词：brood size ; fledging weights ; food ESS ; house sparrow ; offspring survival ; parental care ; parental feeding ; parental provisioning ; Passer domesticus ; recruitment
- 刊名：Animal Behaviour
- 出版年：2008
- 出版时间：January 2008
- 年：2008
- 卷：75
- 期：1
- 页码：291-298
- 全文大小：262 K
文摘
Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables. We here report that SFN is a potent inhibitor of LPS-induced monocyte adhesion, and also blocks the gene expression of the adhesion molecule, ICAM-1, at non-toxic concentrations. Downstream of ICAM-1, NF- κB activity was also found to be abolished in a dose-and time-dependent by SFN in LPS-treated endothelial cells (ECs). SFN exerts its suppressive effects on NF- κB activity in these cells by preventing the degradation of IκB-α. Interestingly, the inhibition of P65 translocation and IκB-α degradation was reversed slightly after 12 hours pretreatment. The intracellular GSH levels in SFN-treated ECs were observed to be reduced, the time course coincident with the suppression of P65 translocation and IκB-α degradation. NAC and GSH reverse the inhibitory effects of SFN upon p65 translocation and IκB-α degradation when preincubated with this agent. Furthermore, the use of BSO to decrease intracellular GSH levels further enhanced the effects of SFN. These data thus suggest that the anti-inflammatory mechanisms of SFN are dependent upon intracellular glutathione level.