Natural History of Idiopathic Diabetes Insipidus

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• 作者：Gail E. Richards ; MD^a ; ^{gail.richards@seattlechildrens.org} ; Michael J. Thomsett ; MBBS ; FRACP^b ; Bruce A. Boston ; MD^c ; Linda A. DiMeglio ; MD^d ; Dorothy I. Shulman ; MD^e ; Martin Draznin ; MD^f
• 关键词：DI ; Diabetes insipidus ; GH ; Growth hormone
• 刊名：The Journal of Pediatrics
• 出版年：2011
• 出版时间：October, 2011
• 年：2011
• 卷：159
• 期：4
• 页码：566-570
• 全文大小：176 K

文摘

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Objective

To determine what percentage of diabetes insipidus (DI) in childhood is idiopathic and to assess the natural history of idiopathic DI.

Study design

We conducted a retrospective chart review of 105 patients with DI who were born or had DI diagnosed between 1980-1989 at 3 medical centers. A second cohort of 30 patients from 6 medical centers in whom idiopathic DI was diagnosed after 1990 was evaluated retrospectively for subsequent etiologic diagnoses and additional hypothalamic/pituitary deficiencies and prospectively for quality of life.

Results

In the first cohort, 11 % of patients had idiopathic DI. In the second cohort, additional hypothalamic/pituitary hormone deficiencies developed in 33 % , and 37 % received an etiologic diagnosis for DI. Health-related quality of life for all the patients with idiopathic DI was comparable with the healthy reference population.

Conclusions

Only a small percentage of patients with DI will remain idiopathic after first examination. Other hormone deficiencies will develop later in one-third of those patients, and slightly more than one-third of those patients will have an etiology for the DI diagnosed. Long-term surveillance is important because tumors have been diagnosed as long as 21 years after the onset of DI. Quality of life for these patients is as good as the reference population.