An improved synthesis of Fmoc-N-methyl serine and threonine

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• 作者：Rajesh H. Bahekar ; Pradip A. Jadav ; Dipam N. Patel ; Vijay M. Prajapati ; Arun A. Gupta ; Mukul R. Jain ; Pankaj R. Patel
• 关键词：Fmoc-N-methyl serine ; Fmoc-N-methyl threonine ; Oxazolidinones ; Lewis acid ; β ; -hydroxy amino acids
• 刊名：Tetrahedron Letters
• 出版年：2007
• 出版时间：16 July 2007
• 年：2007
• 卷：48
• 期：29
• 页码：5003-5005
• 全文大小：110 K

文摘

An improved method for the synthesis of Fmoc-N-methyl serine and threonine has been developed, which involves formation and subsequent reduction of the corresponding oxazolidinone with a Lewis acid under mild conditions, with improved yields and shorter reaction times.