Modulation of heat shock protein 90 affects TGF-β-induced collagen synthesis in human dermal fibroblast cells

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• 作者：Sae Bin Lee^a ; ^b ; A-ram Lim^c ; Dong Kyun Rah^b ; Kyung Soo Kim^d ; Hyun Jin Min^d ; ^{jjinient@gmail.com}
• 关键词：Heat shock protein 90 (Hsp 90) ; Transforming growth factor (TGF)-β ; Collagen ; 17-N-Allylamino-17-demethoxygeldanamycin (17AAG) ; Smad 2/3
• 刊名：Tissue and Cell
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：48
• 期：6
• 页码：616-623
• 全文大小：2443 K
• 卷排序：48

文摘

Modulation of Hsp 90 affects collagen synthesis through regulation of p-SMA pathway. Inhibition of Hsp 90 decreases collagen synthesis through regulation of p-SMAD pathway. Expression of Hsp 90 and collagen is increased in keloid tissues.