Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site
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- 作者：Todd Bradley1 ; 11 ; todd.bradley@duke.edu" class="auth_mail" title="E-mail the corresponding author ; Daniela Fera2 ; 11 ; Jinal Bhiman4 ; 10 ; Leila Eslamizar5 ; Xiaozhi Lu1 ; Kara Anasti1 ; Ruijung Zhang1 ; Laura L. Sutherland1 ; Richard M. Scearce1 ; Cindy M. Bowman1 ; Christina Stolarchuk1 ; Krissey E. Lloyd1 ; Robert Parks1 ; Amanda Eaton1 ; Andrew Foulger1 ; Xiaoyan Nie1 ; Salim S. Abdool Karim6 ; 7 ; Susan Barnett8 ; Garnett Kelsoe1 ; Thomas B. Kepler9 ; S. Munir Alam1 ; David C. Montefiori1 ; M. Anthony Moody1 ; Hua-Xin Liao1 ; Lynn Morris4 ; 6 ; 10 ; Sampa Santra5 ; Stephen C. Harrison2 ; 3 ; Barton F. Haynes1 ; barton.haynes@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：14
- 期：1
- 页码：43-54
- 全文大小：2438 K
文摘
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HIV-1 TF Env immunization induced potent Tier-2 neutralizing antibodies (nAbs)
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Vaccine-elicited nAbs target CD4bs and mimic autologous nAbs in infected individual
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Autologous nAb-Env complex structure reveals mechanism of strain-specific neutralization
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