A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds
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- 作者：Alejandra Bruna1 ; 11 ; Oscar M. Rueda1 ; 11 ; Wendy Greenwood1 ; Ankita Sati Batra1 ; Maurizio Callari1 ; Rajbir Nath Batra1 ; Katherine Pogrebniak1 ; Jose Sandoval1 ; John W. Cassidy1 ; Ana Tufegdzic-Vidakovic1 ; Stephen-John Sammut1 ; Linda Jones1 ; 2 ; Elena Provenzano2 ; Richard Baird1 ; 2 ; Peter Eirew3 ; James Hadfield1 ; Matthew Eldridge1 ; Anne McLaren-Douglas4 ; Andrew Barthorpe4 ; Howard Lightfoot4 ; Mark J. O&rsquo ; Connor5 ; Joe Gray6 ; Javier Cortes7 ; Jose Baselga8 ; Elisabetta Marangoni9 ; Alana L. Welm10 ; Samuel Aparicio3 ; Violeta Serra7 ; Mathew J. Garnett4 ; Carlos Caldas1 ; 2 ; 12 ; carlos.caldas@cruk.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：22 September 2016
- 年：2016
- 卷：167
- 期：1
- 页码：260-274.e22
- 全文大小：8495 K
文摘
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We developed a biobank of breast cancer patient-derived tumor xenografts (PDTXs)
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PDTXs represent diverse molecular subtypes and retain intra-tumor heterogeneity
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PDTX-derived tumor cells (PDTCs) were used for high-throughput drug testing
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PDTXs/PDTCs are a robust platform for pre-clinical pharmacogenomic studies