α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors
详细信息 查看全文
- 作者：Pablo J. Enriori1 ; 11 ; Weiyi Chen1 ; 11 ; Maria C. Garcia-Rudaz1 ; 9 ; Bernadette E. Grayson2 ; 10 ; Anne E. Evans2 ; Sarah M. Comstock2 ; Ursel Gebhardt3 ; Hermann L. Mü ; ller3 ; Thomas Reinehr4 ; Belinda A. Henry1 ; Russell D. Brown1 ; Clinton R. Bruce1 ; Stephanie E. Simonds1 ; Sara A. Litwak1 ; Sean L. McGee5 ; Serge Luquet6 ; Sarah Martinez6 ; Martin Jastroch7 ; Matthias H. Tschö ; p7 ; Matthew J. Watt1 ; Iain J. Clarke1 ; Christian L. Roth8 ; Kevin L. Grove2 ; Michael A. Cowley1 ; michael.cowley@monash.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-MSH ; Pituitary ; Skeletal muscles ; MC5R ; PKA ; Glucose homeostasis
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：5
- 期：10
- 页码：807-822
- 全文大小：1777 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
Glucose stimulates α-MSH release from the pituitary.
- class="label">•
Systemic α-MSH drives glucose disposal and thermogenesis in skeletal muscles.
- class="label">•
α-MSH acts on MC5R expressed on skeletal muscles and activate cAMP-PKA pathway.
- class="label">•
The combined treatment of nonselective or selective PDE 4 inhibitor and α-MSH ameliorates glucose intolerance in obese mice.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |