Distinct roles for metalloproteinases during traumatic brain injury
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- 作者：Si Zhanga ; zhang.si@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Luba Kojica ; lkojic@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Michelle Tsanga ; myt1@sfu.ca" class="auth_mail" title="E-mail the corresponding author ; Parampal Grewala ; parampal.grewal@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jie Liub ; jliu@icord.org" class="auth_mail" title="E-mail the corresponding author ; Dhananjay Namjoshic ; dnamjoshi@cmmt.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Cheryl L. Wellingtonc ; cheryl@cmmt.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Wolfram Tetzlaffb ; tetzlaff@icord.org" class="auth_mail" title="E-mail the corresponding author ; Max S. Cynadera ; cynader@brain.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; William Jiaa ; w.jia@ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Traumatic brain injury ; Closed and open head injury ; Mice model ; Metalloproteinases ; Gelatinase activity ; Immunohistochemistry
- 刊名：Neurochemistry International
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：46-55
- 全文大小：3029 K
文摘
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Two models employed for closed head and open head injuries (CHI & OHI).
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Examined in situ zymography and of MMP-2, -9, ADAM-10, -17 immunohistochemistry.
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In CHI, MMP-2, -9 and ADAM-17's expression increased as at 10 min post injury.
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In OHI, MMP-2 and -9 increased at 24 h post injury with different topography.
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A trauma-induced therapy triggered soon after a primary insult is possible.