- 作者：Gyeong-Hun Park ; Sung Eun Chang ; Chong Hyun Won ; Mi Woo Lee ; Jee Ho Choi ; Kee Chan Moon ; Duck Jong Han ; Su Kil Park ; Jae-Joong Kim ; Jae Won Lee ; Sung-Gyu Lee
- 关键词：Asian ; immunosuppression ; incidence ; Korean ; skin cancer ; transplantation
- 刊名：Journal of the American Academy of Dermatology
- 出版年：March, 2014
- 年：2014
- 卷：70
- 期：3
- 页码：465-472
- 全文大小：283 K
Background
Skin cancer is the most common malignancy to arise after organ transplantation in Caucasians, but limited data are available on its incidence in Asian transplant recipients.Objective
We sought to assess the incidence of skin cancer after organ transplantation in a Korean cohort.
Methods
A cohort study was conducted to determine the incidence and risk factors for skin cancers among kidney, liver, heart, or pancreas transplant recipients, treated at the Asan Medical Center in Seoul, Korea.
Results
The cumulative incidences of skin cancer were 0.70% at 5聽years, 1.66% at 10聽years, and 2.31% at 15聽years. For all skin cancers, squamous cell carcinoma, basal cell carcinoma, and Kaposi sarcoma, the standardized incidence ratios between the recipients and the Korean general population were 30.9 (95% confidence interval, 12.4-63.6), 61.9 (12.8-180.8), 11.9 (0.3-66.1), and 565.2 (68.4-2041.6) after the end of the fifth posttransplantation year, respectively.
Limitations
We cannot exclude the possibility of both the underestimation because of potential missing cases and the overestimation because of the ascertainment bias.
Conclusion
The incidence of posttransplantation skin cancer is very low in Korean patients. However, the risk of skin cancer in organ transplant recipients may be considerably higher than that in the Korean general population.