Association between Low Estimated Glomerular Filtration Rate and Risk of Cerebral Small-Vessel Diseases: A Meta-Analysis

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• 作者：Yuanyuan Liu ; PhD^* ; Pu Lv ; PhD^* ; Haiqiang Jin ; PhD^* ; Wei Cui ; PhD^* ; Chenguang Niu ; PhD^&dagger ; ; Mingming Zhao ; PhD^&dagger ; ; Chenghe Fan ; PhD^* ; Yuming Teng ; PhD^* ; Bing Pan ; MD^&dagger ; ; Qing Peng ; MD^* ; Jingjing Luo ; MD^* ; Lemin Zheng ; PhD^&dagger ; ; ^{zhengl@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yining Huang ; MD^* ; ^{ynhuang@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cerebral small-vessel diseases ; estimated glomerular filtration rate ; chronic kidney impairment ; meta-analysis
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：25
• 期：3
• 页码：710-716
• 全文大小：1444 K

文摘

Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs.

Methods

Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified. A fix effects model was applied and odds ratios (ORs) with 95% confidence intervals were presented.

Results

Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration (OR = 2.20). Stratified analyses consistently showed significant associations across different subtypes, with pooled OR being greatest in subjects with silent cerebral infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate of studies showing OR as a continuous variable showed results consistent with the former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular filtration.

Conclusions

This study revealed that low estimated glomerular filtration was significantly associated with risk of CSVDs. Low estimated glomerular filtration was most strongly associated with SCI (OR = 2.71) among subtypes of CSVDs.