Synthesis and pharmacological evaluation of substituted 5-[4-[2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy]phenyl]methylene]thiazolidine-2,4-dione derivatives as potent euglycemic an
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- 作者：Gupta ; Dipti ; Ghosh ; Narendra Nath ; Chandra ; Ramesh
- 关键词：Euglycemic activity ; Hypolipidemic ; Thiazolidine-2 ; 4-dione
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2005
- 出版时间：February 15, 2005
- 年：2005
- 卷：15
- 期：4
- 页码：1019-1022
- 全文大小：107 K
文摘
A series of substituted 5-[4-[2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy]phenyl]methylene]thiazolidine-2,4-diones were synthesized and their euglycemic and hypolipidemic activities were investigated in Wistar male rats. Based on the in vivo data in rats, compound 4a was identified as a potent euglycemic and hypolipidemic agent.