Toxicity of Cry1A toxins from Bacillus thuringiensis to CF1 cells does not involve activation of adenylate cyclase/PKA signaling pathway

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• 作者：Leivi Portugal ; Carlos Muñ ; ó ; z-Garay¹ ; Diana L. Martí ; nez de Castro ; Mario Soberó ; n ; Alejandra Bravo ; ^{bravo@ibt.unam.mx}
• 关键词：Bacillus thuringiensis ; CF1 cell line ; Cry toxins ; Mechanism of action ; AC/PKA pathway ; MAPK p38
• 刊名：Insect Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：80
• 期：Complete
• 页码：21-31
• 全文大小：1509 K
• 卷排序：80

文摘

Cry1Ab and Cry1Ac toxins induced permeability of K+ ions into CF1 cells. Initial response to Cry1A toxins involves activation of a defense response with phosphorylation of MAPK p38. The AC/PKA signaling pathway is not involved in the toxicity of Cry1Ab or Cry1Ac to CF1 cells. Cry1Ab and Cry1Ac toxins activate apoptosis in CF1.