Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture
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- 作者：Shuangshuang Lua ; b ; Lushuangshuang@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Pan Dua ; Congjia Shanb ; Yaohe Wanga ; Changsheng Mac ; Jianzeng Dongc
- 关键词：Myocardial infarction ; Hand1 ; Cardiac rupture ; MMP9 activity ; Cardiomyocytes apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：478
- 期：4
- 页码：1726-1731
- 全文大小：1434 K
文摘
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Hand1+/− mice survive better than control mice after AMI.
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Hand1+/− mice have less cardiac rupture than control mice after AMI.
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Lower MMP9 activity in Hand1+/− mice contributes to less rupture.
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Less cardiomyocytes apoptosis in Hand1+/− mice contributes to less rupture.
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