Increased microRNA 21 expression contributes to arsenic induced skin lesions, skin cancers and respiratory distress in chronically exposed individuals

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• 作者：Nilanjana Banerjee^a ; ^{2006.nilanjana@gmail.com} ; ^{nilou982000@yahoo.co.in} ; Apurba K. Bandyopadhyay^b ; ^c ; ^{drapurba59@gmail.com} ; Suman Dutta^d ; ^{suman29oct@gmail.com} ; Jayanta K. Das^e ; ^{jayantadas62@gmail.com} ; Tarit Roy Chowdhury^f ; ^{troychowdhury_envstu@school.jdvu.ac.in} ; Arun Bandyopadhyay^a ; ^{arun@iicb.res.in} ; Ashok K. Giri^d ; ^{akgiri15@yahoo.com}
• 关键词：Arsenic ; Human ; Skin cancer ; Micro RNA 21 ; Respiratory problems ; Susceptibility
• 刊名：Toxicology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：378
• 期：Complete
• 页码：10-16
• 全文大小：1012 K
• 卷排序：378

文摘

Increased miR21 expression is found in humans with arsenic induced skin lesions. This in the former group render them more susceptible than the no skin lesion group. miR21 targets become down regulated, the survival PI3K-AKT pathway is activated. Results of the in vitro work validate the above findings. Increased miR21 expression is associated with respiratory problems.