Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: Electrochemical studies on the effects of the quinoidal moiety

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• 作者：Emilay B.T. Diogo ; Gleiston G. Dias ; Bernardo L. Rodrigues ; Tiago T. Guimar?es ; Wagner O. Valen?a ; Celso A. Camara ; Ronaldo N. de Oliveira ; Mauro G. da Silva ; Vitor F. Ferreira ; Yen Galdino de Paiva ; Marilia O.F. Goulart ; Rubem F.S. Menna-Barreto ; Solange L. de Castro ; Eufranio N. da Silva J¨²nior
• 关键词：Lapachol ; ¦Â-Lapachone ; Quinone ; Chagas disease ; Trypomastigote ; Click chemistry ; Electrochemical parameters
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2013
• 出版时间：1 November, 2013
• 年：2013
• 卷：21
• 期：21
• 页码：6337-6348
• 全文大小：1139 K

文摘

In our continued search for novel trypanocidal compounds, twenty-six derivatives of para- and ortho-naphthoquinones coupled to 1,2,3-triazoles were synthesized. These compounds were evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. Compounds 17-24, 28-30 and 36-38 are described herein for the first time. Three of these novel compounds (28-30) were found to be more potent than the standard drug benznidazole, with IC₅₀/24 h values between 6.8 and 80.8 ¦ÌM. Analysis of the toxicity to heart muscle cells led to LC₅₀/24 h of <125, 63.1 and 281.6 ¦ÌM for 28, 29 and 30, respectively. Displaying a selectivity index of 34.3, compound 30 will be further evaluated in vivo. The electrochemical properties of selected compounds were evaluated in an attempt to find correlations with trypanocidal activity, and it was observed that more electrophilic quinones were generally more potent.