Mechanism of inhibition of NiFe hydrogenase by nitric oxide
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- 作者：Pierre Ceccaldi1 ; Emilien Etienne ; Sé ; bastien Dementin ; Bruno Guigliarelli ; Christophe Lé ; ger ; Bé ; né ; dicte Burlat ; burlat@imm.cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydrogenase ; Nitric oxide ; Inhibition mechanism ; EPR spectroscopy ; Protein film voltammetry ; Metalloenzyme
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1857
- 期：4
- 页码：454-461
- 全文大小：817 K
文摘
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Nitric oxide (NO) is a strong inhibitor of standard NiFe hydrogenase.
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NO attacks both the NiFe active site and the iron–sulfur centers chain.
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The mechanism of inhibition at the NiFe active site is complex.
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NO induces irreversible nitrosylation of the medial [3Fe–4S].