- 作者：Kaitlin Roke ; Jessica C. Ralston ; Salma Abdelmagid ; Daiva E. Nielsen ; Alaa Badawi ; Ahmed El-Sohemy ; David W.L. Ma ; David M. Mutch
- 关键词：FA ; fatty acids ; SNPs ; single nucleotide polymorphisms ; FADS1/2 ; fatty acid desaturase gene cluster ; FADS1 ; FADS2 ; fatty acid desaturase 1 and 2 ; hsCRP ; high sensitivity C-reactive protein ; LA ; linoleic acid ; GLA ; ¦Ã-linolenic acid ; DGLA ; dihomo-¦Ã-linole
- 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
- 出版年：2013
- 出版时间：September, 2013
- 年：2013
- 卷：89
- 期：4
- 页码：257-263
- 全文大小：370 K
Introduction
Past research has reported that single nucleotide polymorphisms (SNPs) in fatty acid desaturase 1 and 2 (FADS1/2) can influence plasma fatty acid (FA) profiles. Changes in FA profiles are known to influence inflammatory processes; therefore both FA and SNPs in FADS1/2 may affect inflammation. The goals of this study were to (i) examine the relationships between individual n?6 FA and estimates of FA desaturation with circulating high sensitivity C-reactive protein (hsCRP) levels, and (ii) determine whether SNPs in FADS1/2 are associated with changes in hsCRP.Methods
FA and hsCRP were measured in fasted plasma samples from 878 healthy young adults (20-29 yrs). Circulating levels of plasma linoleic (LA), ¦Ã-linolenic (GLA), dihomo-¦Ã-linolenic (DGLA) and arachidonic (AA) acids were measured by gas chromatography and used to calculate desaturase indices for FADS1/2. Nineteen SNPs in FADS1/2 were genotyped in all subjects and six (rs174579, rs174593, rs174626, rs526126, rs968567 and rs17831757) were further analyzed.
Results
Significant inverse associations were found between LA and hsCRP (p=8.55¡Á10?9) and the FADS1 desaturase index and hsCRP (p=4.41¡Á10?6). A significant positive association was found between DGLA and hsCRP (p=9.10¡Á10?11). Several SNPs were associated with circulating levels of individual FA and desaturase indices, with minor allele carriers having lower AA levels and reduced desaturase indices. A single SNP in FADS2 (rs526126) was weakly associated with hsCRP (p=0.05).
Conclusions
This study highlights the relationships between FA and hsCRP, and confirms that FA are strongly influenced by SNPs in FADS1/2. Furthermore, we found weak evidence that SNPs in FADS1/2 may influence hsCRP levels in young adults.