Novel designed VmCT1 analogs with increased antimicrobial activity

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• 作者：Cibele Nicolaski Pedron^a ; Marcelo Der Torossian Torres^a ; Julia Aparecida da Silva Lima^a ; Pedro Ismael Silva^b ; Fernanda Dias Silva^a ; Vani Xavier Oliveira^a ; ^{vani.junior@ufabc.edu.br}
• 关键词：Antimicrobial peptides ; VmCT1 ; Scorpion venom ; Structure-activity relationship
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：456-463
• 全文大小：956 K
• 卷排序：126

文摘

VmCT1 analogs were proposed with changes in structure and physicochemical properties. Increasing net charge enhances antimicrobial activity and lead to higher helical tendency. Increasing polar angle lead to lower hemolytic activity.