A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia
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- 作者：Akihiko Yokohama ; Anjali Mishra ; Takeki Mitsui ; Brian Becknell ; Jessica Johns ; Douglas Curphey ; Bradley W. Blaser ; Jeffrey B. VanDeusen ; Hsiaoyin Mao ; Jianhua Yu ; Michael A. Caligiuri
- 关键词：Natural killer cell ; NK and T large granular lymphocyte leukemia ; IL-15 ; Proto-oncogene
- 刊名：Leukemia Research
- 出版年：2010
- 出版时间：February 2010
- 年：2010
- 卷：34
- 期：2
- 页码：203-209
- 全文大小：1000 K
文摘
Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive variants of NK and T large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and produce IFN-γ ex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease.