Occupational and Biomass Exposure in COPD: Results of a Cross-Sectional Analysis of the On-Sint Study

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• 作者：José ; Luis Ló ; pez-Campos^a ; ^b ; ^{lcampos@separ.es} ; Alberto Fern&aacute ; ndez-Villar^c ; Carmen Calero-Acuñ ; a^a ; Cristina Represas-Represas^c ; Cecilia Ló ; pez-Ramí ; rez^a ; Virginia Leiro Fern&aacute ; ndez^c ; Ricard Casamor^d ; en nombre de los investigadores del estudio On-Sint
• 关键词：COPD ; Biomass ; Occupational ; Epidemiology ; Geographic distribution
• 刊名：Archivos de Bronconeumología (English Edition)
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：53
• 期：1
• 页码：7-12
• 全文大小：919 K
• 卷排序：53

文摘

Although tobacco smoke is the main risk factor for chronic obstructive pulmonary disease (COPD), other inhaled toxics have also been associated with the disease. The present study analyzes data from exposure to these substances in a cohort of patients with COPD and assesses their impact on the clinical presentation of the disease.MethodsThis is a cross-sectional analysis of the Clinical presentation, diagnosis and course of chronic obstructive pulmonary disease (On-Sint) study. All patients were smokers or ex-smokers as per protocol. In addition, during the inclusion visit patients were enquired about their occupational and biomass exposure history. The clinical features of patients with and without an added risk factor to tobacco were compared and those significant were entered in a multivariate logistic regression analysis, expressed as odds ratio (OR).ResultsThe sample size was 1214 patients with COPD, of which 1012 (83.4%) had tobacco as the only risk factor and 202 (16.6%) had additional ones, mainly 174 (14.3%) with occupational gases and 32 (2.6%) with biomass exposure. The geographical distribution of this exposure showed a preference for the northern parts of the country and the East coast. The biomass exposure was rather low. Male gender (OR: 2.180), CAT score (OR: 1.036) and the use of long-term oxygen therapy (OR: 1.642) were associated with having an additional risk factor in the multivariate analysis.ConclusionsOccupational exposures are more common than biomass in Spain. COPD caused by tobacco plus other inhalants has some differential features and a more impaired quality of life.