Global vasomotor dysfunction and accelerated vascular aging in β-thalassemia major
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- 作者：George Hahalis ; Dimitrios T. Kremastinos ; George Terzis ; Andreas P. Kalogeropoulos ; Athina Chrysanthopoulou ; Marina Karakantza ; Alex ; ra Kourakli ; Stamatis Adamopoulos ; Alex ; ros D. Tselepis ; Nikos Grap
- 关键词：Thalassemia ; Carotid atherosclerosis ; Endothelium ; Iron-overload ; Inflammation
- 刊名：Atherosclerosis
- 出版年：2008
- 出版时间：June 2008
- 年：2008
- 卷：198
- 期：2
- 页码：448-457
- 全文大小：501 K
文摘
Patients with β-thalassemia major (β-TM) demonstrate an increased incidence of vascular complications, which are thought to result from a procoagulant/proinflammatory environment. We investigated the arterial vasorelaxing capacity and sought for early carotid atherosclerosis and underlying pathophysiological correlates in these transfusion-dependent patients.