Drug loading of foldable commercial intraocular lenses using supercritical impregnation
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- 作者：A. Bouledjouidjaa ; abir.gch@hotmail.fr" class="auth_mail" title="E-mail the corresponding author ; abir.bouledjouidja@etu.univ-amu.fr" class="auth_mail" title="E-mail the corresponding author ; Y. Masmoudia ; yasmine.masmoudi@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author ; M. Sergentb ; V. Trivedic ; A. Meniaid ; E. Badensa ; elisabeth.badens@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Poly (2-hydroxyethyl methacrylate) (PubChem CID ; 13360) ; Dexamethasone 21-phosphate disodium (PubChem CID ; 16961) ; Ciprofloxacin (PubChem CID ; 2764) ; Carbon dioxide (PubChem CID ; 280) ; Ethanol (PubChem CID ; 702) ; Disodium hydrogenophosphate (PubChem CID ; 24203) ; Monobasic potassium phosphate (PubChem CID ; 516951)
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：16 March 2016
- 年：2016
- 卷：500
- 期：1-2
- 页码：85-99
- 全文大小：2537 K
文摘
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Preparation of therapeutic drug loaded intraocular lenses (IOLs).
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Supercritical impregnation of foldable IOLs with drug components in order to combine cataract surgery and postoperative treatment in single procedure.
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Foaming phenomena avoided by coupling slow pressurization and depressurization phases.
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Deep and reproducible impregnations.
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A prolonged drug release profile.