MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells

详细信息    查看全文

• 作者：Syunsuke Noguchi^a ; ^{o5104401@edu.gifu-u.ac.jp"" rel=""nofollow} ; Takashi Mori^b ; ^c ; Yuki Hoshino^b ; ^c ; Kohji Maruo^b ; ^c ; Nami Yamada^a ; Yukio Kitade^d ; Tomoki Naoe^e ; Yukihiro Akao^c ; ^d
• 关键词：Bladder cancer ; MicroRNA-143 ; Tumor suppressor ; ERK5 ; Akt
• 刊名：Cancer Letters
• 出版年：2011
• 出版时间：28 August 2011
• 年：2011
• 卷：307
• 期：2
• 页码：211-220
• 全文大小：1196 K

文摘

MicroRNA (miR)-143 and -145 were down-regulated in human bladder cancer T24 cells. The enforced expression of miR-143 induced growth-suppression in T24 cells through down-regulation of ERK5 and Akt expression at translational level, and chemically-modified synthetic miR-143 (miR-143/BP) exhibited a greater growth inhibitory effect than wild-type miR-143. In addition, the synthetic miR-143/BP induced apoptotic cell death in some of the transfected cells. Furthermore, co-treatment with the synthetic miR-143/BP and cisplatin showed the additive growth-suppressing effect on T24 cells. These findings suggest that the chemically-modified synthetic miR-143 functions as a tumor suppressor in T24 cells by targeting ERK5 and/or Akt.