Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma
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- 作者：Qiulian Lia ; b ; e ; 1 ; Chao Zhangc ; 1 ; Ruichao Chena ; 1 ; Hanzhen Xionga ; Fuman Qiua ; Shaoyan Liua ; Minfen Zhanga ; Fang Wangb ; Yu Wangc ; Xuan Zhoud ; Guohong Xiaob ; xiaogh66@163.com" class="auth_mail" title="E-mail the corresponding author ; Xudong Wangd ; wxd.1133@163.com" class="auth_mail" title="E-mail the corresponding author ; Qingping Jianga ; b ; Jiangqp2003@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endometrioid endometrial carcinoma ; MALAT1 ; miR-200c ; Invasion
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：383
- 期：1
- 页码：28-40
- 全文大小：5012 K
文摘
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The relationship of miR-200c and MALAT1 expression is reverse in EEC.
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miR-200c binds to MALAT1 and forms MALAT1/miR-200c sponge in EEC.
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MALAT1 and miR-200c are reciprocally repressed.
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Targeting miR-200c/MALAT1 could inhibit EMT, invasion and cytoskeleton remodeling in EEC.