Palladium-Catalyzed Direct Amination of Allylic Alcohols in Aqueous Media
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- 作者：Prof. Dr. Zhengyin Du ; Yufei Yan ; Dr. Ying Fu and Dr. Kehu Wang
- 刊名：Asian Journal of Organic Chemistry
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：5
- 期：6
- 页码：812-818
- 全文大小：458K
- ISSN：2193-5815
文摘
Palladium chloride-catalyzed amination of allylic alcohols with aromatic amines in the presence of triphenylphosphine and trifluoroacetic acid in the aqueous phase gave a wide range of allylamines in good to excellent yields under mild conditions. This protocol has a wide substrate scope and broad functional group tolerance. It is an environmentally friendly and highly atom-economical method for N-allylamine synthesis. A plausible mechanism involving a (π-allyl)palladium complex intermediate is proposed.