Total Syntheses of Sarcandrolide J and Shizukaol D: Lindenane Sesquiterpenoid [4+2] Dimers

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• 作者：Changchun Yuan ; Biao Du ; Heping Deng ; Yi Man and Prof. Dr. Bo Liu
• 刊名：Angewandte Chemie
• 出版年：2017
• 出版时间：January 9, 2017
• 年：2017
• 卷：129
• 期：2
• 页码：652-655
• 全文大小：1165K
• ISSN：1521-3757

文摘

The syntheses of members of a family of lindenane sesquiterpenoid [4+2] dimers led to the total syntheses of sarcandrolide J and shizukaol D. Inspired by a modified biosynthetic pathway, a cascade featuring furan formation/alkene isomerization/Diels–Alder cycloaddition was devised to construct the congested polycyclic architecture of the target molecules with the correct stereochemistry. This study presents a pioneering synthetic entry to this family of natural products and paves the way for fully exploring their biological functions.