Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects

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• 作者：Jö ; rg Tä ; ubel ; Georg Ferber ; Gabriel Fox ; Sara Fernandes ; Ulrike Lorch and A. John Camm
• 刊名：British Journal of Clinical Pharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：83
• 期：2
• 页码：339-348
• 全文大小：772K
• ISSN：1365-2125

文摘

The D₂/D₃ antagonist amisulpride has shown promising efficacy against postoperative nausea and vomiting (PONV) at low doses. We investigated whether intravenous amisulpride has an effect on the QTc interval in a formal Thorough QT study (TQT).