Asian consensus on the relationship between obesity and gastrointestinal and liver diseases

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• 作者：Jianyi Calvin Koh ; Wai Mun Loo ; Khean Lee Goh ; Kentaro Sugano ; Wah Kheong Chan ; Wai Yan Philip Chiu ; Myung-Gyu Choi ; Sutep Gonlachanvit ; Wei-Jei Lee ; Wei Jie Jonathan Lee ; Yeong Yeh Lee ; Laurentius A Lesmana ; You-Ming Li ; Chun Jen Liu ; Bunzo Matsuura ; Atsushi Nakajima ; Enders Kwok Wai Ng ; Jose D Sollano ; Simon Kin Hung Wong ; Vincent W S Wong ; Yunsheng Yang ; Khek Yu Ho and Yock Young Dan
• 刊名：Journal of Gastroenterology and Hepatology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：31
• 期：8
• 页码：1405-1413
• 全文大小：1203K
• ISSN：1440-1746

文摘

The incidence of obesity is increasing in Asia, with implications on gastrointestinal (GI) and liver diseases. The Gut and Obesity in Asia Workgroup comprises regional experts with the aim of studying relationship between obesity and the GI and liver diseases in Asia. Through literature review and the modified Delphi process, consensus statements examining the impact of obesity on esophageal, gastric, pancreatic, colorectal, and liver diseases, exploring relationship between gut microbiome and obesity, and assessing obesity therapies have been produced by the Gut and Obesity in Asia Workgroup. Sixteen experts participated with 9/15 statements having strong consensus (>80% agreement). The prevalence of obesity in Asia is increasing (100% percentage agreement in brackets), and this increased prevalence of obesity will result in a greater burden of obesity-related GI and liver diseases (93.8%). There was consensus that obesity increases the risk of gastric cancer (75%) and colorectal neoplasia (87.5%). Obesity was also associated with Barrett's esophagus and esophageal adenocarcinoma (66.7%) and pancreatic cancer (66.7%) in Asia. The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asia is on the rise (100%), and the risk of NAFLD in Asia (100%) is increased by obesity. Obesity is a risk factor for the development of hepatocellular carcinoma (93.8%). Regarding therapy, it was agreed that bariatric surgery was an effective treatment modality for obesity (93.8%) but there was less agreement on its benefit for NAFLD (62.5%). These experts' consensus on obesity and GI diseases in Asia forms the basis for further research, and its translation into addressing this emerging issue.