Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction
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- 作者：Xin Yu ; Jiadong Hu ; Zhigao Shen ; Prof. Dr. Hui Zhang ; Prof. Dr. Jin-Ming Gao and Prof. Dr. Weiqing Xie
- 刊名：Angewandte Chemie
- 出版年：2017
- 出版时间：January 2, 2017
- 年：2017
- 卷：129
- 期：1
- 页码：356-359
- 全文大小：856K
- ISSN：1521-3757
文摘
Oxidative ring contraction of cyclic α-formyl ketones was facilitated by the action of H2O2 under operationally simple and environmentally benign reaction conditions. The process was highly regioselective and enables stereospecific construction of contiguous quaternary all-carbon centers from stereodefined all-substituted all-cyclic ketones. The asymmetric syntheses of (+)-cuparene and (+)-tochuinyl acetate were also successively achieved by taking advantage of this novel protocol.