A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C−H Bonds
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- 作者：Dr. Bo Su ; Dr. Tai-Gang Zhou ; Dr. Xian-Wei Li ; Xiao-Ru Shao ; Pei-Lin Xu ; Dr. Wen-Lian Wu ; Prof. Dr. John F. Hartwig and Prof. Dr. Zhang-Jie Shi
- 刊名：Angewandte Chemie International Edition
- 出版年：2017
- 出版时间：January 19, 2017
- 年：2017
- 卷：56
- 期：4
- 页码：1092-1096
- 全文大小：1054K
- ISSN：1521-3773
文摘
Iridium catalysts containing dative nitrogen ligands are highly active for the borylation and silylation of C−H bonds, but chiral analogs of these catalysts for enantioselective silylation reactions have not been developed. We report a new chiral pyridinyloxazoline ligand for enantioselective, intramolecular silylation of symmetrical diarylmethoxy diethylsilanes. Regioselective and enantioselective silylation of unsymmetrical substrates was also achieved in the presence of this newly developed system. Preliminary mechanistic studies imply that C−H bond cleavage is irreversible, but not the rate-determining step.