We use Continuous Renal Replacement Therapy for Overdoses and Intoxications

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• 作者：Valerie Jorge Cabrera and Anushree C. Shirali
• 刊名：Seminars in Dialysis
• 出版年：2016
• 出版时间：July–August 2016
• 年：2016
• 卷：29
• 期：4
• 页码：275-277
• 全文大小：70K
• ISSN：1525-139X

文摘

Extracorporeal modalities for the removal of drugs and toxins are indicated for the treatment of overdoses and intoxications. Well-established modalities include hemodialysis (HD), high-flux HD (HfD), and charcoal hemoperfusion (HP). Recently, there have been increasing reports on the use of continuous renal replacement therapy (CRRT), such as continuous veno-venous hemodialysis (CVVHD), continuous veno-venous hemofiltration (CVVH) or CVVH combined with dialysis (CVVHDF). In the present article, we will discuss the various factors that determine the clearance of drugs and toxins and accordingly, we will propose that with few exceptions, CRRT does not have a role in the routine management of intoxications.