Arterio-venous fistula for automated red blood cells exchange in patients with sickle cell disease: Complications and outcomes

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• 作者：Marianne Delville ; Sandra Manceau ; Nassim Ait Abdallah ; Jan Stolba ; Sameh Awad ; Thibaud Damy ; Barnabas Gellen ; Laurent Sabbah ; Karima Debbache ; Vincent Audard ; Jean-Louis Beaumont ; Cé ; cile Arnaud ; Christelle Chantalat-Auger ; Fran&ccedil ; oise Driss ; Fran&ccedil ; ois Lefrè ; re ; Marina Cavazzana ; Gilbert Franco ; Frederic Galacteros ; Jean-Antoine Ribeil and Justine Gellen-Dautremer
• 刊名：American Journal of Hematology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：92
• 期：2
• 页码：136-140
• 全文大小：418K
• ISSN：1096-8652

文摘

Erythrocytapheresis (ER) can improve outcome in patients with sickle cell disease (SCD). A good vascular access is required but frequently it can be difficult to obtain for sickle cell patients. Arterio-venous fistulas (AVFs) have been suggested for ER in SCD supported by limited evidence. We report the largest cohort of ER performed with AVFs from three French SCD reference centers. Data of SCD patients undergoing ER with AVFs in the French SCD reference center were retrospectively collected. The inclusion criteria were: SS or Sβ-Thalassemia and AVF surgery for ER. SCD-related complications, transfusion history, details about AVF surgical procedure, echocardiographic data before and after AVF, AVF-related surgical and hemodynamical complications were collected. Twenty-six patients (mean age 20.5 years, mean follow-up 68 months [11–279]) were included. Twenty-three patients (88.5%) required central vascular access before AVF. Fifteen AVFs (58%) were created on the forearm and 11 (42%) on the arm. Nineteen patients (73%) had stenotic, thrombotic or infectious AVF complications. A total of 0.36 stenosis per 1,000 AVF days, 0.37 thrombosis per 1,000 AVF days and 0.078 infections per 1.000 AVF days were observed. The mean AVF lifespan was 51 months [13–218]. One patient with severe pulmonary hypertension worsened after AVF creation and died. We report the first series of SCD patients with AVF for ER, demonstrating that AVFs could be considered as a potential vascular access for ER. Patients with increased risk for hemodynamic intolerance of AVFs must be carefully identified, so that alternative vascular accesses can be considered. Am. J. Hematol. 92:136–140, 2017.