Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner
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- 作者：Cynthia J Koziol-White ; Edwin J Yoo ; Gaoyuan Cao ; Jie Zhang ; Eleni Papanikolaou ; Ivan Pushkarsky ; Adam Andrews ; Blanca E Himes ; Robert D Damoiseaux ; Stephen B Liggett ; Dino Di Carlo ; Richard C Kurten and Reynold A Panettieri Jr.
- 刊名：British Journal of Pharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：173
- 期：18
- 页码：2726-2738
- 全文大小：1160K
- ISSN：1476-5381
文摘
Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness (AHR). Although the molecular mechanisms remain unclear, activation of specific PI3K isoforms mediate inflammation and AHR. We aimed to determine whether inhibition of PI3Kδ evokes dilation of airways and to elucidate potential mechanisms.