Located in Yangchun basin of western Guangdong Province,the Shilu deposit has developed oxidized Cu and skarn Cu-Mo ore bodies.The skarn ore body genetically is associated with the Shilu granodiorite. The results show that the five molybdenite samples from quartz-vein-type ore have 187Re-187Os model ages ranging from(104±1.5) Ma to(104.6±1.5)Ma,with an average of(104.34±0.66)Ma and an isochron age of(104.1±1.3)Ma,consistent with the age of the related granodiorite(107±0.72Ma),which implies that the mineralization took place in the early Cretaceous.Based on previous studies,it is suggested that the Shilu skarn Cu-Mo deposit was formed later than 50Ma when the Jurassic Cu-Fe deposits in Yanchun basin were generated,thus belonging to the large-scale Cretaceous mineralization in South China.