The exploration practice and integrated sequence-stratigraphic studies for years demonstrated that the Oligocene-Miocene boundary was an important transfer interface of sedimentary-tectonic-climate conditions in the Pearl River Mouth Basin and corresponded to the Baiyun movement (in about 23.8 Ma), during which the seafloor spreading ridge of the South China Sea jumped, was deflected and accompanied with material source changes of the paleo-Pearl River. This event resulted in the shift of the shelf slope-break zone from the neighborhood of the southern uplift area of the Baiyun Depression in Late Oligocene to the northern slope in Miocene. Moreover, the shelf slope-break zone has basically stood there since about 21 Ma. Integrated investigations basically demonstrated that reservoir-seal assemblages of the Oligocene Pearl River coast-delta-deepwater fan depositional system and Neogene deepwater deposits were major objective strata for further exploration.