Cambrian intermediate-acid intrusive rocks (U-Pb age (511+29) Ma) distribute widely around the Kusilafu region at the north margin of the Westem Kunlun. The intrusive rocks can be subdivided into early and later periods according to contact relationships. The early intrusion is greyish porphyritic quartz (monzonite) diorite, characterized by poor-SiO2 moderate-alkaline, high-Ca and strongly peraluminous, and is relatively low in ZREE with LREE enrichment ((La/Yb)N, 11.65 on average) and moderate negative Eu anomaly (δEu varied from 0.40 to 0.71, 0.73 on average). While the later is offwhite porphyritic coarse-grained (monzonite) granite characterized by rich-Si, low-Ca, rich-K and peraluminous, and is relatively enriched in ZREE with an enrichment of LREE ((La/Yb)y average at 10.19) and moderate negative Eu anomaly (6Eu varied from 0.40 to 0.71, averaged at 0.73). The early intrusion is larger with widespread outcrops, and belongs to I-type granite, whereas the later is smaller, and belongs to S-type granite, which intruded into the early one. Both intrusions formed in an island arc tectonic setting likely associated with the Kunlun Ocean subduction. The difference is that the early one formed at the active continental (the Western Kunlun) margin while the later were formed in the subduction zone; they were both results of partial melting crust from different source regions of the upper subducting oceanic crust.