The Hehuaping tin-polymetallic deposit is a large-scale deposit newly discovered in Southern Hunan province It consists of four main ore bodies located in the Southeast portion of the Wangxianling granite pluton. The granitiod rocks are distinguished as two epochs: Indosinian biotite granite and Yanshanian granite porphyry dike. Tin-polymetal mineralization is related to the Indosinian middle-coarse grained biotite granite and the Yanshanian intensely altered granite porphyry dike. The granitic rocks are rich in Si (SiO2 〉 70%), Al (Al2O3=11.06%-18.26%), K2O+Na2O contents varying from 3.51% to 8.18%, with K2O 〉 Na2O, A/CNK=0.93~2.85, enriched in trace elements such as Rb, Ta, La, Nd, Zr and Hf, and depleted in Ba, K and Sr, Eu/Eu* values of the rocks vary from 0.06 to 0.34, indicating the rocks are calc-alkaline, peraluminous S-type granite. The εNd(t) values of the granitiod rocks vary in range of-7.1 to -11.2, and two stages Nd model ages (t2DM) range from 1509 Ma to1903 Ma, showing that the granitoids were derived from remelting of the Mesoproterozoic basement rocks. Considering that the eNd(t) values of the rocks are higher than the mean value of the South China crust (-12.1), and the rather high zircon εHf(t) values of the granitic rocks (-10.14 to + 4.61), we suggest that the mantle contribution is significant. The tin mineralization is closely related to the mantle participation.