Zhaxikang antimony polymetallic ore deposit, the first super large deposit discovered in northern Himalayan metallogenic belt (NHMB) and first SEDEX discovered modified by hot spring type Mn-Fe-Sb-Pb-Zn-Ag deposit in China, is the marked prospecting breakthrough in the youngest and great southern Tibetan detachment system (STDS). Many detailed field surveys and comprehensive researches have been made to seek evidence of SEDEX and hot spring mineralization. The results indicate that Zhaxikang is the SEDEX modified by hot spring type deposit. Based on the analysis of characteristics of ore deposit and its genetic type, the discovery process and exploration advance were introduced, which is of great significance both in the prospecting theories and practices, and in the exploration and evaluation, scientific research, and theory innovation in NHMB.