In Kumishen area the two-mica granite was emplaced in the Mesoproterozoic Xingxingxia Group in eastern part of South Tianshan Mountains. Based on geological setting and geochemical characteristics, it is showed that two-mica granite source rocks derive from Xingxingxia Group metapelites. It is produced in a transitional tectonic setting from continental collision tectonic environment of late orogenic epoch to post-collisonal, which probably represents completion of the collisional orogeny between Tarim Plate and Yili-Kazakstan plate in Early Permian, as well as entering into a post-collisional evolution stage in Kumishi area in eastern part of South Tianshan.