The middle-lower reaches of the Yangtze River region is an important metallogenic belt of iron, copper and polymetallic in East China. It includes mainly skarn-type, stratabound skarn-type, porphyry-type, pulp-type, porphyrite-type iron and copper-polymetallic deposit in this region. Metal deposits are widely distributed in the calcareous skarn. Generally, the metal deposits in this area should be permeable magmatic fluid ore-forming system. In the depth of skarn-porphyry copper deposit in Dongguashan (1 km) and copper deposit in Anqing (2.7 km, estimated), the authors pay attention to the breadth and intensity of the skarn and alkaline(potassium and sodium), which can be used as an important sign of deep prospecting.