Guizhou Depression has experienced three stages of tectonic evolution, i.e., the early Proto-Tethys rift basin and the late orogenic fold, ancient Tethys rift basin stage, and the Neo-Tethys oroganic transformation phase. The results show that the Upper Paleozoic marine shale, characterized by high abundance of organic matter, good types and high-over-mature stage of evolution, has favorable conditions for shale gas. Up to date, Upper Paleozoic shale has been found in many gas shows in Guizhong Depression, which has similar geological condition to typical shale gas basins in eastern United States(Appalachian, Ford Voss and Michigan Basin).