More than 390 volcanoes with various size and shape are distributed along a 1 000 km long belt, from Nuominhe volcanic cluster in Elunchun in the north of Daxinanling Mountains, through Arshan-Chaihe volcanic cluster, and Xilinhot-Abaga volcanic cluster, to Wulanhada volcanic cluster in Right-back-banner, Chahaer. These volcano clusters form the spectacular Quaternary volcano eruption belt in the NNE direction in the East Inner Mongolia. On the whole, volcanic activities are controlled by the NNE basement faults. However, in the specific case, volcanoes are mostly located at the intersection areas of the NE and NW basement deep fault. Neotectonics in the region are closely related to volcanic activity. Intrusion of deep magma is likely to the main cause of controlling the neotectonic activity in the region. In particular, the spatial distribution of the Holocene volcanism shows the activity of the neotectonics in the eastern Inner Mongolia.