In the depletion exploitation process for the gas field, the reservoir pore pressure was generally decreased, leading to the weak 4D seismic effect, which restricts the application of 4D seismic technology in the exploitation management of the gas field. Based on the detailed modeling studies, fine consistent amplitude compensation and careful selection of seismic parameters, it was found that some amplitude attribute for the top of the reservoir decreased 5 percent after 5 years of exploitation, showing the existence of 4D seismic effect for the depletion exploitation gas field. Therefore 4D seismic techniques can be used to monitor the production performance of the oil and gas reservoir, and provide basis for oil and gas field development deployment.