Particular destroy phenomena occurred in the main building of Shuimo Silicon Company near the fault produced by the 2008 Wenchuan earthquake. On the basis of site investigation, two dimensional finite element models is set up, and the hazard effect of a building caused by the faulting is simulated. The simulation result may be used to explain the mechanism for the formation of the particular destroys phenomena of the building during the earthquake. It is thought that the formation of fault altered the local stress field and acceleration, thus led to the differential destroy of the building at the hanging wall of the fault which is characterized by the stronger destroy near the fault. The destroy of the main beam is caused by the co-action of axial stress and shear stress.