The first-row transition metals and trace noble metals are highly enriched in sulfide minerals. This paper summarizes some geological background of sulfide minerals, the analysis significance of trace metals in sulfides, the advantages and recent applications of LA-ICP-MS in quantitative analysis of major and trace elements in sulfide minerals, related argide and oxide interferences and the development of four methods of synthetic sulfide reference materials for trace elements including PGEs and Au. By comparing the four synthetic methods, it was found that the method of sintering at high temperature or high pressure is the most promising method for synthetic sulfide reference materials at present.