The southern Guizhou Depression is located in the southwestern margin of the Xuefengshan uplift. Its structural outline spreads from NNE to SN and it has the accommodate trait. Based on seismology, MT (telluric electromagnetic sounding) and geologic survey, the study shows there are different strikes towards the southern Luodian rift-depress and northern Middle Guizhou uplift, and there is a two-layer epimetamorphosed and deep-seated crystallized basement in the southern Guizhou Depression. The depression has gone through three periods for basin formation and three periods for basin and orogen transforming. There are four types of basins and the modern structural pattern and mode are actually resulted from compound, association and superposition of multistage tectonic deformations.