Recent studies in the Yardoi gneiss dome (YGD) of the Tethyan Himalaya, have demonstrated that the Tethyan Himalayan belt experienced a major episode of crustal melting at Mid-Eocene (44~40 Ma) time, represented by the formation of a suite of high Sr/Y two-mica granites. Petrographic observations, zircon U-Pb age and geochemical data show that: 1) the Lhunze-Qiaga rhyolitic subvolcanic rocks formed at ca.43~41 Ma and may represent the shallow counterpart of the two-mica granites crystallized at a much deeper level; 2) in contrast with the two-mica granites, the subvolcanic rocks had experienced intensive hydrothermal-magmatic interactions as well as An-rich plagioclase fractional crystallization as evidenced by pronounced negative Eu anomalies, much lower Sr concentrations, and enhanced common Pb and U concentrations in the magmatic zircon; and 3) these two suites of rocks formed a Mid-Eocene igneous edifice under crustal thickened conditions.