The study of the Paleozoic tectonics and endogenic metallogeny in the Tianshan-Altay region constitutes an important and interesting project. The Altay area belongs to Early Paleozoic collision zone, and the Tianshan area belongs to the early period of Late Paleozoic(Late Devonian-Early Carboniferous) collision zone; they both resulted from nearly NS-trending shortening and collision. In Asian continent, the strongest collision period is not necessarily the most favorable period for endogenic metallogeny, and therefore the orogenic metallogeny hypothesis" should be treated carefully. Some suggestions concerning the prospecting for concealed endogenic metallogenic ore deposits are also put forward in this paper.