The Shilu copper deposit in Yangchun city, Guangdong province is located at southwest of the NNE-strike Wuchuan-Sihui fault. LA-ICP-MS U-Pb dating of zircons from a pyrite (-chalcopyrite)-mincralizcd granodiorite sample from the Shilu Copper deposit yielded a weighted mean 206pb/E38u age of 107.2±2.0 Ma, consistent with the results obtained from two non-mineralized granodiorite samples of the Shilu pluton (106.7±1.4 Ma and 104.1±2.0 Ma, respectively) within analytical errors. This indicates that the mineralization was closely related to the emplacement of the granodiorite pluton. Early to Late Yanshanian shoshonitic to calc-alkaline intrusive rocks are widespread in the Shilu area, suggestive of a lithospheric extension tectonic setting. Accordingly, the formation of the Shilu copper deposit might have resulted from the ma~matic activity induced by this lithosnheric extension.